In this study, we found that FGE displayed inhibition properties against C. In addition, FGE could help improve the antibiotic susceptibility of these strains to some traditional antibiotics. Fresh Garlic Extract may be a candidate for the treatment of infections by multi-drug resistant strains. Our results suggest that FGE helps improve the antibiotic resistance of pathogens to some antibiotics. With the increased abuse of synthetic antibiotics and the continuing spread of strains with multi-drug resistance, the need for alternative agents is urgent.
Garlic has been demonstrated to be a powerful remedy to protect against infections of many bacteria, fungi and viruses 12 - Of all its reputed benefits, one significant advantage of garlic is its effectiveness against nosocomial strains that frequently display above average resistance to many antibiotics. Garlic contains various active components that work in complex ways. Some of these components can work together in the body to protect against infections.
Of all the biotical ingredients, allicin, an organ sulfur compound, is regarded as the paramount antibacterial agent in crushed garlic extracts and exhibits protective effects against attacks by pests 14 , However, allicin is rapidly oxidized, unstable and volatile, meaning it rapidly breaks down after raw garlic is cracked.
It has been reported that garlic extract has more potent anti-staphylococcal activity than an equal amount of allicin. Systemic fungal infections induced by C. Some researchers reported on the antifungal activity of garlic in vitro against C. In this study, C.
Fresh garlic extracts showed a powerful inhibitory effect against C. Thus it can be suggested that FGE can distinctly improve the sensitivity of C.
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An et al. Another study showed that a combination of F and allicin exhibited a good synergism against C. Some underlying mechanisms have been suggested by previous studies. Low et al. Yousuf et al. Methicillin-resistant Staphylococcus aureus is often considered to be as a "superbug" Garlic has been scientifically proven to be a powerful natural antibiotic against MRSA infections 12 , Ingredients in fresh garlic, other than illicit, have strong natural antibiotic effects Garlic extract, DAS and DADS provide powerful protective activity against MRSA by affecting the pathogen distribution and plasma levels of pro-inflammatory cytokines, endothelial injury-associated proteins, and coagulation and anti-coagulation factors as well as lipid oxidation levels, and by boosting the immune system.
Pseudomonas aeruginosa contributes to chronic opportunistic infections, which can be fatal for immunocompromised patients and the elderly 5 , 20 , Biofilms of P. The antimicrobial activity of garlic against P. Garlic-treated biofilms were susceptible to both tobramycin and polymorphonuclear leukocytes PMNs grazing. Furthermore, the PMNs incubated with garlic-treated biofilms showed an increase in respiratory burst activation.
The garlic treatment initially provoked a higher degree of inflammation and significantly improved clearing of the infecting bacteria These findings are not in accordance with previous studies This may be due to the variability of the strains or differences among species of garlic. In this study, the results indicated that FGE has inhibition properties against C.
Fresh Garlic Extract may be used to aid the treatment of infections from multi-drug resistant strains.
The pungent antibiotic
In addition, further efforts are needed to elucidate the molecular mechanisms underlying the synergistic effect between antibiotics and FGE in vitro. Critical revision of the manuscript for important intellectual content: Chaofeng Sun, and Jiru Xu. Statistical analysis: Xudong Ma. National Center for Biotechnology Information , U. Journal List Jundishapur J Microbiol v. Jundishapur J Microbiol. Published online May Author information Article notes Copyright and License information Disclaimer.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4. This article has been cited by other articles in PMC.
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Abstract Background: Infections caused by strains with multi-drug resistance are difficult to treat with standard antibiotics. Objectives: In this study, we used the disk diffusion method to investigate the antimicrobial activities of FGE and the combination of antibiotics with FGE, on methicillin-resistant Staphylococcus aureus MRSA , Pseudomonas aeruginosa and Candida albicans, to evaluate the interactions between antibiotics and FGE.
Results: Fresh garlic extract displayed evident inhibition properties against C. Conclusions: The results suggest that FGE can improve the antibiotic sensitivity of these pathogens to some antibiotics.
Background With antibacterial drugs being widely used in clinical settings, many microorganisms, especially methicillin-resistant Staphylococcus aureus MRSA , Pseudomonas aeruginosa and Candida albicans , have adapted to synthetic antibiotics and become highly resistant to these drugs over time 1 - 4.
Materials and Methods 3. Microbial Strains A total of 90 clinical isolates and three control strains were used. Reproducibility and Statistics All measurements were repeated three times and each strain was examined at least three separate times. Results 4. Candida albicans The antifungal susceptibility of C. Open in a separate window. Figure 1.
Garlic for the Treatment of Topical Infections: Does It Help?
Figure 2. Pseudomonas aeruginosa The antibacterial susceptibility of P. Figure 3.
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References 1. Increased expression of virulence attributes in oral Candida albicans isolates from human immunodeficiency virus-positive individuals. J Med Microbiol. Evaluation of various methods for the detection of meticillin-resistant Staphylococcus aureus strains and susceptibility patterns.
Transcriptional regulation of drug-resistance genes in Candida albicans biofilms in response to antifungals. Strateva T, Yordanov D. Pseudomonas aeruginosa - a phenomenon of bacterial resistance. Effect of antifungal treatment on the prevalence of yeasts in HIV-infected subjects. Smith K, Hunter IS. I recommend chopping or crushing a raw garlic clove and letting it sit for about 10 minutes before eating it, in order to release the enzymes that are converted into allicin.
Infection Benefits From Garlic - Garlic | HowStuffWorks
Start by eating about one clove of garlic every day to prevent bacterial infections. You can also find raw garlic in powder, oil, extract and tablet forms. Onions : Onions—a food often thrown into soups, stews and stir fries—contain powerful flavonoids that have antibiotic effects, and, like garlic, they contain therapeutic sulfur compounds called cysteine sulphoxides.
When using onions for their medicinal benefits, cut one open and let it sit for about 10 minutes to increase the phytonutrient content. Echinacea : Echinacea is a powerful immune system stimulator that can fight a number of infections, including those caused by bacteria. Additionally, when echinacea is taken as soon as symptoms develop, it can help cut the duration of illnesses that are sometimes treated with antibiotics.